Water → HCID 12049758, compound

HRID 1935328Notes

Reaction equation

HRID 1935328 reaction equation
[CH:1]1([C:4]2[CH:8]=[C:7]([NH2:9])[NH:6][N:5]=2)[CH2:3][CH2:2]1.C(=O)([O-])O.[Na+].[C:15]1([N:21]=[C:22]=[O:23])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.O>C(O)C>[NH2:9][C:7]1[N:6]([C:22]([NH:21][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[O:23])[N:5]=[C:4]([CH:1]2[CH2:3][CH2:2]2)[CH:8]=1

Participants

6

Reactant 4

HCID 962WaterHCID 7672Phenyl isocyanateHCID 516892Sodium BicarbonateHCID 178507266HCID 178507266, compound

Product 1

HCID 12049758HCID 12049758, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To 0.4 g (3.2 mmol) of 3-cyclopropyl-5-amino-1H-pyrazole in 10 ml of 95% ethanol containing 0.3 g of sodium hydrogencarbonate 0.35 ml (3 mmol) of phenylisocyanate were added dropwise over several minutes. After 30 min water was added, and the solid was filtered, washed with 10% HCl and then with water. The filtrate was concentrated in vacua. The crude was recrystallized from methanol/water to give white peddles of 5-amino-3-cyclopropyl-N-phenyl-1H-pyrazole-l-carboxamide,

Workup

  1. filtrationthe solid was filtered
  2. washwashed with 10% HCl
  3. concentrationThe filtrate was concentrated in vacua
  4. customThe crude was recrystallized from methanol/water

Sources & evidence

ORD record
ord-c06ba8fff24e48a6bb781bb83a424d9a
Source dataset
uspto-grants-2002_05
Patent number
US06387900B1

Reaction notes

Loading…