Hydrazine hydrate (1:1) → HCID 178507266, compound

HRID 1935331Notes

Reaction equation

HRID 1935331 reaction equation
[CH:1]1([C:4](=O)[CH2:5][C:6]#[N:7])[CH2:3][CH2:2]1.O.[NH2:10][NH2:11]>C(O)C>[CH:1]1([C:4]2[CH:5]=[C:6]([NH2:7])[NH:11][N:10]=2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 98127633-Cyclopropyl-3-oxopropanenitrile

Product 1

HCID 178507266HCID 178507266, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5 g (0.046 mol) of 3-cyclopropyl-3-oxo-propanenitrile were dissolved in 200 ml of ethanol and 2.26 ml (0.046 mol) of hydrazine hydrate were added. The solution was maintained at reflux for 5 hours and then the solvent evaporated under vacuum. The residue was redissolved with methylene chloride and washed several times with brine. The organic layer was dried over anhydrous sodium sulfate and the solvent evaporated to give 4.53 g (80% yield) of the title compound.

Workup

  1. temperatureThe solution was maintained
  2. temperatureat reflux for 5 hours
  3. customthe solvent evaporated under vacuum
  4. dissolutionThe residue was redissolved with methylene chloride
  5. washwashed several times with brine
  6. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  7. customthe solvent evaporated

Sources & evidence

ORD record
ord-bf53784739e745efa63c4a90f8ac10f6
Source dataset
uspto-grants-2002_05
Patent number
US06387900B1

Reaction notes

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