反应详情

To a stirred suspension of sodium ethanethiolate (600 mg, 5.75 mmol) in dry THF (25 mL) was added 3-bromo-2-cyanopyridine (700 mg, 3.83 mmol). The reaction mixture was heated to reflux under N2 for 3 h. The solvent was removed in vacuo and the resulting residue was taken Lip in CH2Cl2 (35 mL). The solution was filtered to remove precipitated sodium bromide and the filtrate was concentrated at reduced pressure to afford the title compound as a yellow oil:

1. temperatureThe reaction mixture was heated
2. temperatureto reflux under N2 for 3 h
3. customThe solvent was removed in vacuo
4. filtrationThe solution was filtered
5. customto remove
6. customprecipitated sodium bromide
7. concentrationthe filtrate was concentrated at reduced pressure