1-(2-Aminoethyl)-4-(2-methoxyphenyl)piperazine → HCID 9846831, compound

HRID 1935474Notes

Reaction equation

HRID 1935474 reaction equation
[NH2:1][CH2:2][CH2:3][N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[O:16][CH3:17])[CH2:6][CH2:5]1.C(O[CH:21]=[N:22][C:23]1[S:24][C:25]([C:34](=[O:38])[N:35]([CH3:37])[CH3:36])=[C:26]([CH3:33])[C:27]=1[C:28](OCC)=[O:29])C>C(O)C>[CH3:33][C:26]1[C:27]2[C:28](=[O:29])[N:1]([CH2:2][CH2:3][N:4]3[CH2:5][CH2:6][N:7]([C:10]4[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=4[O:16][CH3:17])[CH2:8][CH2:9]3)[CH:21]=[N:22][C:23]=2[S:24][C:25]=1[C:34](=[O:38])[N:35]([CH3:37])[CH3:36]

Participants

4

Reactant 2

HCID 103991861-(2-Aminoethyl)-4-(2-methoxyphenyl)piperazineHCID 54432745HCID 54432745, compound

Product 1

HCID 9846831HCID 9846831, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.9 g (8.0 mmol) of 1-(2-aminoethyl)-4-(2-methoxyphenyl)piperazine were added to 2.4 g (7.8 mmol) of 2-ethoxymethyleneamino-3-carboethoxy-4-methyl-5-dimethylcarbamoylthiophene in 30 ml of ethanol, and the mixture was boiled at reflux for 2 h. After standing overnight, the product crystallized out and was filtered off with suction and washed with a little ethanol. 2.2 g (62%) of product, having a m.p. of 188-190° C., were isolated.

Workup

  1. temperatureat reflux for 2 h
  2. customthe product crystallized out
  3. filtrationwas filtered off with suction
  4. washwashed with a little ethanol
  5. customwere isolated

Sources & evidence

ORD record
ord-b22f68274d854a4bbcf6d7a22908bea5
Source dataset
uspto-grants-2002_05
Patent number
US06387912B1

Reaction notes

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