4-Methoxyphenol → HCID 22325203, compound

HRID 1935575Notes

Reaction equation

HRID 1935575 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[CH:5][CH:4]=1.[F:10][C:11]1[CH:18]=[CH:17][C:14]([CH2:15]Cl)=[CH:13][CH:12]=1>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([OH:9])=[C:5]([CH2:15][C:14]2[CH:17]=[CH:18][C:11]([F:10])=[CH:12][CH:13]=2)[CH:4]=1

Participants

3

Reactant 2

HCID 90154-MethoxyphenolHCID 96024-Fluorobenzyl chloride

Product 1

HCID 22325203HCID 22325203, compound

Procedure

Alkylation of 4-methoxyphenol with 4-fluorobenzyl chloride according to the procedure described in J. Chem. Soc, 2431 (1958) gave 4-methoxy-2-(4′-fluorobenzyl)phenol. This material was converted to compound 69 and compound 70 byu the procedure similar to that in Example 18 method B.

Sources & evidence

ORD record
ord-096ad88c4f25419c8c32cf6dd4581476
Source dataset
uspto-grants-2002_05
Patent number
US06387924B2

Reaction notes

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