HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → Ethanaminium, 2-(4-((1Z)-1,2-diphenyl-1-buten-1-yl)phenoxy)-N,N,N-trimethyl-, iodide (1:1)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Tamoxifen | HCID 2733526 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Ethanaminium, 2-(4-((1Z)-1,2-diphenyl-1-buten-1-yl)phenoxy)-N,N,N-trimethyl-, iodide (1:1) | HCID 3033898 | 99% |
Reaction Steps
Tamoxifen methiodide was prepared by reacting 2.0 g of tamoxifen (Aldrich Chemical Co., St. Louis, Mo.) with methyl iodide at 0° C. for 24 hours. Ethyl acetate was then added to afford a white precipitate, which was recrystallized from methanol to yield >99% tamoxifen methiodide. Tamoxifen benzyl bromide was synthesized by reacting tamoxifen with benzyl bromide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06387955B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-9289aa982ee14005bf9d28cc4fd75557 |
| Source note | uspto-grants-2002_05 |