反应详情

Tamoxifen methiodide was prepared by reacting 2.0 g of tamoxifen (Aldrich Chemical Co., St. Louis, Mo.) with methyl iodide at 0° C. for 24 hours. Ethyl acetate was then added to afford a white precipitate, which was recrystallized from methanol to yield >99% tamoxifen methiodide. Tamoxifen benzyl bromide was synthesized by reacting tamoxifen with benzyl bromide.

1. customTamoxifen methiodide was prepared
2. customat 0° C.
3. customfor 24 hours
4. customto afford a white precipitate, which
5. customwas recrystallized from methanol