反应详情

Ethyl N-(2,3-dichloro-6-nitrobenzyl)glycine (compound VI) may also be catalytically hydrogenated using a sulfided platinum on carbon catalyst under hydrogen pressure. The catalyst is then removed by filtration and the filtrate concentrated, diluted with water and an organic solvent and basified using an alkali to a pH of about 9-10. The organic phase is separated and concentrated and the crude material purified by low temperature recrystallization to give ethyl-(6-amino-2,3-dichlorobenzyl)glycine (compound I).

1. customThe catalyst is then removed by filtration
2. concentrationthe filtrate concentrated
3. additiondiluted with water
4. customThe organic phase is separated
5. concentrationconcentrated
6. customthe crude material purified by low temperature recrystallization