HCID 178419844, compound → HCID 178420191, compound

HRID 1935753Notes

Reaction equation

HRID 1935753 reaction equation
[CH2:1]([CH:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[C:10]([C:17]2[N:18]=[CH:19][NH:20][CH:21]=2)=[CH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(O)C>[CH2:1]([CH:8]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:10]([C:17]2[N:18]=[CH:19][NH:20][CH:21]=2)[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 178419844HCID 178419844, compound

Product 1

HCID 178420191HCID 178420191, compound

Reagents, catalysts & solvents 1

HCID 702EthanolCatalyst

Procedure

4-(3-benzyl-3H-inden-1-yl)-1H-imidazole was hydrogenated in ethanol using 10% palladium on charcoal as a catalyst. The mixture was filtered through Celite, and the solvent was evaporated. The crude 4-(3-benzyl-2,3-dihydro-1H-inden-1-yl)-1H-imidazole which was the mixture of the cis and trans diastereomers (the ratio 94:6) was purified by flash chromatography (elution with a dichloromethane—methanol gradient).

Workup

  1. filtrationThe mixture was filtered through Celite
  2. customthe solvent was evaporated
  3. additionthe mixture of the cis and trans diastereomers (the ratio 94:6)
  4. customwas purified by flash chromatography (
  5. washelution with a dichloromethane—methanol gradient)

Sources & evidence

ORD record
ord-aa346ef395a643b6b2c86c2e1a86b3ca
Source dataset
uspto-grants-2002_05
Patent number
US06388090B2

Reaction notes

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