Potassium Carbonate → 1-(1-Ethoxycyclopropyl)-4-ethynyl-2-tert-butylbenzene

HRID 1935902Notes

Reaction equation

HRID 1935902 reaction equation
[CH2:1]([O:3][C:4]1([C:7]2[CH:12]=[CH:11][C:10]([C:13]#[C:14][Si](C)(C)C)=[CH:9][C:8]=2[C:19]([CH3:22])([CH3:21])[CH3:20])[CH2:6][CH2:5]1)[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO>[CH2:1]([O:3][C:4]1([C:7]2[CH:12]=[CH:11][C:10]([C:13]#[CH:14])=[CH:9][C:8]=2[C:19]([CH3:20])([CH3:22])[CH3:21])[CH2:6][CH2:5]1)[CH3:2]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 22568955[4-(1-Ethoxycyclopropyl)-3-tert-butyl-phenylethynyl]-trimethylsilane2×

Product 1

HCID 225688751-(1-Ethoxycyclopropyl)-4-ethynyl-2-tert-butylbenzene

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using General Procedure E; [4-(1-ethoxycyclopropyl)-3-tert-butyl-phenylethynyl]-trimethylsilane (Intermediate 111, 215.0 mg, 0.69 mmol) in methanol (10 mL) was treated with potassium carbonate (80.0 mg, 0.58 mmol) and stirred overnight at ambient temperature. The crude alkyne, 169 mg, was used directly in the next reaction.

Sources & evidence

ORD record
ord-099cfeb6d3384f098af482131cfa8b5d
Source dataset
uspto-grants-2002_05
Patent number
US06387892B1

Reaction notes

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