Potassium Carbonate → HCID 22568938, compound

HRID 1936105Notes

Reaction equation

HRID 1936105 reaction equation
[CH2:1]([O:3][C:4]1([C:7]2[CH:12]=[CH:11][C:10]([C:13]#[C:14][Si](C)(C)C)=[CH:9][C:8]=2[CH:19]([CH3:21])[CH3:20])[CH2:6][CH2:5]1)[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO>[CH2:1]([O:3][C:4]1([C:7]2[CH:12]=[CH:11][C:10]([C:13]#[CH:14])=[CH:9][C:8]=2[CH:19]([CH3:20])[CH3:21])[CH2:6][CH2:5]1)[CH3:2]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 22569012[4-(1-Ethoxycyclopropyl)-3-isopropyl-phenylethynyl]-trimethylsilane2×

Product 1

HCID 22568938HCID 22568938, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using General Procedure E; [4-(1-ethoxycyclopropyl)-3-isopropyl-phenylethynyl]-trimethylsilane (Intermediate 102, 210.0 mg, 0.70 mmol) in methanol (10 mL) was treated with potassium carbonate (100.0 mg, 0.72 mmol) and stirred overnight at ambient temperature. The crude alkyne was used directly in the next reaction.

Sources & evidence

ORD record
ord-e0240c25832c4c7aa2f24096214dd6cb
Source dataset
uspto-grants-2002_05
Patent number
US06387951B1

Reaction notes

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