Potassium Carbonate → HCID 22568804, compound

HRID 1936153Notes

Reaction equation

HRID 1936153 reaction equation
[CH3:1][C:2]1[CH:13]=[C:12]([C:14]#[C:15][Si](C)(C)C)[CH:11]=[CH:10][C:3]=1[CH2:4][N:5]1[CH:9]=[CH:8][N:7]=[CH:6]1.C(=O)([O-])[O-].[K+].[K+]>CO>[C:14]([C:12]1[CH:11]=[CH:10][C:3]([CH2:4][N:5]2[CH:9]=[CH:8][N:7]=[CH:6]2)=[C:2]([CH3:1])[CH:13]=1)#[CH:15]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 225689641-(2-Methyl-4-trimethylsilanylethynyl-benzyl)-1H-imidazole2×

Product 1

HCID 22568804HCID 22568804, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using General Procedure E; 1-(2-methyl-4-trimethylsilanylethynyl-benzyl)-1H-imidazole (Intermediate 140, 140.0 mg, 0.53 mmols) in methanol (5 mL) was treated with potassium carbonate (100.0 mg, 0.72 mmol) and stirred overnight at ambient temperature. The crude alkyne (105 mg, 100%) was used directly in the next reaction.

Sources & evidence

ORD record
ord-9204e4808112481c8ae7f85caa4e7ee1
Source dataset
uspto-grants-2002_05
Patent number
US06387951B1

Reaction notes

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