3-Fluoro-4-methoxyaniline → 2,3,4-Trifluoro-1-[(3-Fluoro-4-methoxyphenyl)aminosulfonyl]benzene

HRID 1936202Notes

Reaction equation

HRID 1936202 reaction equation
[F:1][C:2]1[C:7]([F:8])=[C:6]([F:9])[CH:5]=[CH:4][C:3]=1[S:10](Cl)(=[O:12])=[O:11].[F:14][C:15]1[CH:16]=[C:17]([CH:19]=[CH:20][C:21]=1[O:22][CH3:23])[NH2:18]>>[F:1][C:2]1[C:7]([F:8])=[C:6]([F:9])[CH:5]=[CH:4][C:3]=1[S:10]([NH:18][C:17]1[CH:19]=[CH:20][C:21]([O:22][CH3:23])=[C:15]([F:14])[CH:16]=1)(=[O:12])=[O:11]

Participants

3

Reactant 2

HCID 5811103-Fluoro-4-methoxyanilineHCID 27769772,3,4-Trifluorobenzenesulfonyl chloride

Product 1

HCID 120168752,3,4-Trifluoro-1-[(3-Fluoro-4-methoxyphenyl)aminosulfonyl]benzene

Procedure

The title compound was prepared in a manner similar to that described in Example 1, by replacing 4-fluoro-3-nitrophenylsulfonyl chloride with 2,3,4-trifluorophenylsulfonyl chloride and replacing p-anisidine with 3-fluoro-4-methoxyaniline. 1H-NMR (CDCl3): δ 7.52 (1H, m), 7.00 (1H, m), 6.93 (1H, m), 6.80 (2H, m), 6.70 (1H, br s), 3.80 (3H, s).

Sources & evidence

ORD record
ord-257e858b74b149049dacd207c4933253
Source dataset
uspto-grants-2002_05
Patent number
US06388131B2

Reaction notes

Loading…