Benzyl Chloride → 1-Bromo-4-phenylmethoxybenzene

Participants

Reaction Steps

First, 53.2 g of benzyl chloride, 69.2 g of 4-bromophenol, 110.4 g of potassium carbonate, and 800 ml of methyl ethyl ketone were put in a 2 flask, and stirred under reflux for 30 minutes. After the reaction, insoluble material was filtered off, and the solvent was distilled off from the filtrate. Ether and a 2% sodium hydroxide aqueous solution were added to the residue to separate an organic layer. The organic layer was washed with a saturated brine and dried with sodium sulfate. The solvent was then distilled off. The residue was distilled (b.p. 131° C. to 140° C./0.08 mmHg), to obtain 61.0 g (Y: 58.07%) of 4-bromo-1-benzyloxybenzene. The purity of the resultant compound was 99.0% as measured by GC.

Provenance & Evidence