反应详情

温度

120 °C

A mixture of 1.6 g of 5-chloro-2,4-dinitrotoluene and 20 mL of N,N-dimethyl-thioformamide is heated to 120° C. for 16 hours. After cooling to room temperature, the mixture is purified by flash column chromatography on silica gel, eluting with 3% to 10% ethyl acetate/hexanes to provide 0.78 g of 6-methyl-5-nitrobenzothiazole as a yellow solid.

1. temperatureAfter cooling to room temperature
2. customthe mixture is purified by flash column chromatography on silica gel
3. washeluting with 3% to 10% ethyl acetate/hexanes