HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1936589Generated: October 26, 2026
N,N-Dimethylthioformamide → 6-Methyl-5-nitrobenzothiazole
https://huagongshe.com/reaction/1936589
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N,N-Dimethylthioformamide | HCID 69794 | — |
| Reactant | 5-Chloro-2,4-dinitrotoluene | HCID 253802 | — |
| Product | 6-Methyl-5-nitrobenzothiazole | HCID 22462215 | — |
Reaction Steps
A mixture of 1.6 g of 5-chloro-2,4-dinitrotoluene and 20 mL of N,N-dimethyl-thioformamide is heated to 120° C. for 16 hours. After cooling to room temperature, the mixture is purified by flash column chromatography on silica gel, eluting with 3% to 10% ethyl acetate/hexanes to provide 0.78 g of 6-methyl-5-nitrobenzothiazole as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06391878B2 |
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| Source dataset | uspto-grants-2002_05 |
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| ORD ID | ord-134a7e30664c40f18f61160a6911d1c5 |
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| Source note | uspto-grants-2002_05 |
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