反应详情

The tri-hydrochloride salt of the product of Example 8, step 3 (2 g, 4.3 mmol) and 4-amino-2,6-dimethyl benzoic acid (710 mg, 4.3 mmol) (see preparation below) were subjected to the standard coupling conditions (EDC/HOBT/iPr2NEt). Purification via flash chromatography (2/1 hexanes/acetone, SiO2) gave 1.16 g (52%) of 8AA as a yellow foam.

1. customPurification via flash chromatography (2/1 hexanes/acetone, SiO2)
2. customgave 1.16 g (52%) of 8AA as a yellow foam