HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-amino-2,6-dimethylbenzoic acid → 4-[(Ethylamino)carbonylamino]-2,6-dimethyl benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-amino-2,6-dimethylbenzoic acid | HCID 313682 | — |
| Reactant | HCID 86583922 | HCID 86583922 | — |
| Product | 4-[(Ethylamino)carbonylamino]-2,6-dimethyl benzoic acid | HCID 20619421 | — |
Reaction Steps
The tri-hydrochloride salt of the product of Example 8, step 3 (2 g, 4.3 mmol) and 4-amino-2,6-dimethyl benzoic acid (710 mg, 4.3 mmol) (see preparation below) were subjected to the standard coupling conditions (EDC/HOBT/iPr2NEt). Purification via flash chromatography (2/1 hexanes/acetone, SiO2) gave 1.16 g (52%) of 8AA as a yellow foam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06391865B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-dfc4c7c4495d461c99c33c9d9a382a9e |
| Source note | uspto-grants-2002_05 |