Bis(2-chloroethyl)amine → 5-(piperazin-1-yl)-1H-indole

HRID 1936609Notes

Reaction equation

HRID 1936609 reaction equation
NC1C=C2C(=CC=1)NC=C2.ClCCNCCCl.[NH:18]1[C:26]2[C:21](=[C:22]([N:27]3[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]3)[CH:23]=[CH:24][CH:25]=2)[CH:20]=[CH:19]1>>[NH:18]1[C:19]2[C:24](=[CH:23][C:22]([N:27]3[CH2:28][CH2:29][NH:30][CH2:31][CH2:32]3)=[CH:21][CH:20]=2)[CH:25]=[CH:26]1

Participants

4

Reactant 3

HCID 9533Bis(2-chloroethyl)amineHCID 788675-AminoindoleHCID 5945904-(piperazin-1-yl)-1H-indole

Product 1

HCID 221748205-(piperazin-1-yl)-1H-indole

Procedure

This piperazine was prepared by treatment of 5-aminoindole with and bis(2-chloroethyl)amine by a procedure analogous to the procedure described above for the preparation of 1-(1H-indol-4-yl)piperazine.

Sources & evidence

ORD record
ord-d997dcdb17cb4fc2be2c4668148367ab
Source dataset
uspto-grants-2002_05
Patent number
US06391882B1

Reaction notes

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