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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1936609Generated: November 2, 2026

Bis(2-chloroethyl)amine → 5-(piperazin-1-yl)-1H-indole

https://huagongshe.com/reaction/1936609

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBis(2-chloroethyl)amineHCID 9533—
Reactant5-AminoindoleHCID 78867—
Reactant4-(piperazin-1-yl)-1H-indoleHCID 594590—
Product5-(piperazin-1-yl)-1H-indoleHCID 22174820—

Reaction Steps

This piperazine was prepared by treatment of 5-aminoindole with and bis(2-chloroethyl)amine by a procedure analogous to the procedure described above for the preparation of 1-(1H-indol-4-yl)piperazine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06391882B1
Source datasetuspto-grants-2002_05
ORD IDord-d997dcdb17cb4fc2be2c4668148367ab
Source noteuspto-grants-2002_05