Isobutyryl chloride → HCID 135670781, compound

HRID 1936644Notes

Reaction equation

[C:1](Cl)(=[O:5])[CH:2]([CH3:4])[CH3:3].[NH2:7][C:8]1[CH:9]=[CH:10][C:11]([O:25][CH2:26][CH3:27])=[C:12]([C:14]2[NH:15][C:16](=[O:24])[C:17]3[N:23]=[CH:22][CH:21]=[CH:20][C:18]=3[N:19]=2)[CH:13]=1>>[C:1]([NH:7][C:8]1[CH:9]=[CH:10][C:11]([O:25][CH2:26][CH3:27])=[C:12]([C:14]2[NH:15][C:16](=[O:24])[C:17]3[N:23]=[CH:22][CH:21]=[CH:20][C:18]=3[N:19]=2)[CH:13]=1)(=[O:5])[CH:2]([CH3:4])[CH3:3]

Participants

Reactant 2

HCID 62325Isobutyryl chloride

HCID 135482279HCID 135482279, compound

Product 1

HCID 135670781HCID 135670781, compound

Procedure

The title compound was prepared using isobutyryl chloride and 2-(5-amino-2-ethoxyphenyl)pyrido[3,2-d]pyrimidin-4(3H)-one (Example 20), following the procedure of Example 12, and was obtained as a white solid (80%), m.p. 256-259° C.

Sources & evidence

ORD record: ord-4752c0d55b264c16b8d0ccb206a5d626
Source dataset: uspto-grants-2002_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06391885B1

Reaction notes

Loading…