3-Amino-1-propanol → HCID 135670780, compound

HRID 1936660Notes

Reaction equation

HRID 1936660 reaction equation
CS[C:3]1[N:8]=[C:7]2[N:9]=[C:10]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[O:20][CH2:21][CH2:22][CH3:23])[NH:11][C:12](=[O:13])[C:6]2=[CH:5][N:4]=1.[NH2:24][CH2:25][CH2:26][CH2:27][OH:28]>C(O)C>[OH:28][CH2:27][CH2:26][CH2:25][NH:24][C:3]1[N:8]=[C:7]2[N:9]=[C:10]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[O:20][CH2:21][CH2:22][CH3:23])[NH:11][C:12](=[O:13])[C:6]2=[CH:5][N:4]=1

Participants

4

Reactant 2

HCID 90863-Amino-1-propanolHCID 1355223017-Methylthio-4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4,5-d]pyrimidine

Product 1

HCID 135670780HCID 135670780, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In a similar manner to Example 38, reaction of 7-methylthio-4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4,5-d]pyrimidine (0.45 g) and 3-amino-1-propanol (0.98 g) in ethanol (15 ml) yielded the title compound, 0.31 g, m.p. 185-6° C. (recrystallized from ethanol).

Workup

  1. customyielded
  2. customthe title compound, 0.31 g, m.p. 185-6° C. (recrystallized from ethanol)

Sources & evidence

ORD record
ord-aaa01de5b2b14fcb9cbf9fc069faf2b9
Source dataset
uspto-grants-2002_05
Patent number
US06391885B1

Reaction notes

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