1-Propanol, sodium salt (1:1) → 7-Propoxy-4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4,5-d]pyrimidine

HRID 1936674Notes

Reaction equation

HRID 1936674 reaction equation
CS([C:5]1[N:10]=[C:9]2[N:11]=[C:12]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[O:22][CH2:23][CH2:24][CH3:25])[NH:13][C:14](=[O:15])[C:8]2=[CH:7][N:6]=1)(=O)=O.[O-:26][CH2:27][CH2:28][CH3:29].[Na+]>>[CH2:27]([O:26][C:5]1[N:10]=[C:9]2[N:11]=[C:12]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=3[O:22][CH2:23][CH2:24][CH3:25])[NH:13][C:14](=[O:15])[C:8]2=[CH:7][N:6]=1)[CH2:28][CH3:29]

Participants

3

Reactant 2

HCID 236693631-Propanol, sodium salt (1:1)HCID 1356707527-Methylsulphonyl-4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4,5-d]pyrimidine

Product 1

HCID 1356707627-Propoxy-4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4,5-d]pyrimidine

Procedure

In a similar manner to Example 63 reaction of 7-methylsulphonyl-4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4,5-d]pyrimidine (0.54 g) and sodium propoxide solution (from sodium, 0.17 g, and n-propanol, 25 ml) yielded the title compound, 0.19 g, m.p. 157-8° C. (recrystallized from n-propanol).

Workup

  1. customyielded
  2. customthe title compound, 0.19 g, m.p. 157-8° C. (recrystallized from n-propanol)

Sources & evidence

ORD record
ord-4bb0029a7dbc4fa8b5c2ace2eaf8e336
Source dataset
uspto-grants-2002_05
Patent number
US06391885B1

Reaction notes

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