Methylamine → HCID 135670772, compound

HRID 1936685Notes

Reaction equation

HRID 1936685 reaction equation
CS[C:3]1[N:4]=[N:5][C:6]2[N:12]=[C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[O:19][CH2:20][CH2:21][CH3:22])[NH:10][C:9](=[O:23])[C:7]=2[N:8]=1.[CH3:24][NH2:25]>>[CH3:24][NH:25][C:3]1[N:4]=[N:5][C:6]2[N:12]=[C:11]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[O:19][CH2:20][CH2:21][CH3:22])[NH:10][C:9](=[O:23])[C:7]=2[N:8]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 135670760HCID 135670760, compound

Product 1

HCID 135670772HCID 135670772, compound

Procedure

5,6-Dihydro-3-methylthio-5-oxo-7-(2-propoxyphenyl)pyrimido[5,4-e][1,2,4]triazine (340 mg) was treated with a solution of methylamine in industrial methylated spirit (33%, 15 ml) at 70° C. in a pressure vessel (172 kPa) for 10 hours. The cooled reaction mixture was evaporated under reduced pressure to afford a yellow solid (290 mg) which was recrystallized from ethanol and then acetonitrile to afford the title compound, 120 mg, m.p. decomposes over 260° C.

Workup

  1. customThe cooled reaction mixture
  2. customwas evaporated under reduced pressure

Sources & evidence

ORD record
ord-6534b8f63e0d47f2bbd9488e2e880f0b
Source dataset
uspto-grants-2002_05
Patent number
US06391885B1

Reaction notes

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