2-Hydrazino-delta-2-imidazoline hydrobromide → HCID 69536384, compound

HRID 1936741Notes

Reaction equation

HRID 1936741 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][CH:10]=O)=[CH:4][CH:3]=1.Br[CH2:13][CH2:14][CH:15]([NH:21][C:22]([O:24][CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)=[O:23])[C:16]([O:18]CC)=[O:17].Br.[NH:33]1[CH2:37][CH2:36][N:35]=[C:34]1[NH:38][NH2:39]>>[NH:35]1[CH2:36][CH2:37][N:33]=[C:34]1[NH:38][N:39]=[CH:10][CH2:9][CH2:8][C:5]1[CH:4]=[CH:3][C:2]([O:1][CH2:13][CH2:14][C@@H:15]([C:16]([OH:18])=[O:17])[NH:21][C:22]([O:24][CH2:25][C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=2)=[O:23])=[CH:7][CH:6]=1

Participants

4

Reactant 3

HCID 30850992-Hydrazino-delta-2-imidazoline hydrobromideHCID 119574273-(4-Hydroxyphenyl)propanalHCID 15857342HCID 15857342, compound

Product 1

HCID 69536384HCID 69536384, compoundYield 8.4%

Procedure

The operation is carried out as in Example 1 Stages A, B and C but using 190 mg of 3-(4-hydroxyphenyl)-propanal and 530 mg of ethyl 4-bromo-2-[[(phenylmethoxy)carbonyl]amino]butanoate (Stage A) then, during Sage B, 92 mg of 4,5-dihydro-1H-imidazol-2-yl-hydrazine hydrobromide. 20 mg of expected product is obtained in the form of an E/Z mixture 90/10.

Sources & evidence

ORD record
ord-1297fa6957e84c208427efa3e1fe2ce6
Source dataset
uspto-grants-2002_05
Patent number
US06391904B1

Reaction notes

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