Acetic Anhydride → 6-(5-Methyl-1,3,4-oxadiazol-2-yl)quinazolin-4-one

HRID 1936756Notes

Reaction equation

HRID 1936756 reaction equation
N1[C:5]([C:6]2[CH:7]=[C:8]3[C:13](=[CH:14][CH:15]=2)[N:12]=[CH:11][NH:10][C:9]3=[O:16])=[N:4][N:3]=N1.[C:17](OC(=O)C)(=[O:19])[CH3:18]>>[CH3:18][C:17]1[O:19][C:5]([C:6]2[CH:7]=[C:8]3[C:13](=[CH:14][CH:15]=2)[N:12]=[CH:11][NH:10][C:9]3=[O:16])=[N:4][N:3]=1

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 178518710HCID 178518710, compound

Product 1

HCID 1357038826-(5-Methyl-1,3,4-oxadiazol-2-yl)quinazolin-4-one

Procedure

6-(1,2,3,4-Tetrazol-5-yl)-quinazolin-4-one (3.31 g) was treated with acetic anhydride (115 ml) at reflux under N2 for 1 hour. The anhydride was removed in vacuo, the residue absorbed onto silica and purified by chromatography to give the title compound as a white solid (3.47 g). The analytical data was consistent with that given earlier.

Workup

  1. temperatureat reflux under N2 for 1 hour
  2. customThe anhydride was removed in vacuo
  3. customthe residue absorbed onto silica
  4. custompurified by chromatography

Sources & evidence

ORD record
ord-ccef36120bcf4fa4a796a2bc1ea45cc2
Source dataset
uspto-grants-2002_05
Patent number
US06391874B1

Reaction notes

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