Acetic Anhydride → 6-(5-Methyl-1,3,4-oxadiazol-2-yl)quinazolin-4-one

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Reaction Steps

6-(1,2,3,4-Tetrazol-5-yl)-quinazolin-4-one (3.31 g) was treated with acetic anhydride (115 ml) at reflux under N2 for 1 hour. The anhydride was removed in vacuo, the residue absorbed onto silica and purified by chromatography to give the title compound as a white solid (3.47 g). The analytical data was consistent with that given earlier.

Provenance & Evidence