反应详情

6-(5-Trifluoromethyl-1,3,4-oxadiazol-2-yl)quinazolin-4-one 6-(1,2,3,4-Tetrazol-5-yl)-quinazolin-4-one (1.0 g) was treated with trifluoroacetic anhydride (50 ml) at 50° C. under N2 for 5 hours. The anhydride was removed in vacuo, the residue absorbed onto silica and purified by chromatography to give the title compound as a white solid (0.79 g); δH [2H6]DMSO 12.63(1H,bs), 8.71(1H,d), 8.45(1H,dd), 8.27(1H,s), 7.90(1H,d); m/z (M−1+) 281.

1. customThe anhydride was removed in vacuo
2. customthe residue absorbed onto silica
3. custompurified by chromatography