反应详情

1-Methyl-5-formyl imidazole (0.64 g) was treated with ethylene glycol (0.3 ml), p-toluenesulphonic acid monohydrate (0.0015 g) and powdered 4A molecular seives under N2 for 18 hours at reflux. Subsequent cooling and filtration was followed by washing of the organic phase with aqueous sodium carbonate solution (2N), drying and concentration to give the title compound; δH (CDCl3) 7.43 (1H,s), 7.12 (1H,s), 5.91 (1H,s), 4.10(4H,m), 3.70(3H,s).

1. customfor 18 hours
2. temperatureat reflux
3. temperatureSubsequent cooling
4. filtrationfiltration
5. washby washing of the organic phase with aqueous sodium carbonate solution (2N)
6. customdrying
7. concentrationconcentration