Sodium Hydroxide → HCID 86584189, compound

HRID 1936975Notes

Reaction equation

HRID 1936975 reaction equation
C([O:3][C:4]([CH2:6][O:7][C:8]1[CH:30]=[CH:29][C:11]2[CH2:12][CH2:13][CH2:14][C@H:15]([NH:17][CH2:18][C@H:19]([OH:28])[CH2:20][O:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH2:16][C:10]=2[CH:9]=1)=[O:5])C.[OH-].[Na+:32]>C(O)C>[OH:28][C@H:19]([CH2:20][O:21][C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)[CH2:18][NH:17][C@H:15]1[CH2:14][CH2:13][CH2:12][C:11]2[CH:29]=[CH:30][C:8]([O:7][CH2:6][C:4]([O-:5])=[O:3])=[CH:9][C:10]=2[CH2:16]1.[Na+:32]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 70130482HCID 70130482, compound

Product 1

HCID 86584189HCID 86584189, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of (2S)-1-[((6S)-3-ethoxycarbonylmethoxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-6-yl)amino]-3-phenoxy-2-propanol (249 mg) in ethanol (1 ml) was added 1N sodium hydroxide at 5° C. After stirred at room temperature for 2 hours, the mixture was evaporated in vacuo to afford sodium [(6S)-6-[((2S)-2-hydroxy-3-phenoxypropyl)amino]-6,7,8,9-tetrahydro-5H-benzocyclohepten-3-yloxy]acetate (210 mg).

Workup

  1. customthe mixture was evaporated in vacuo

Sources & evidence

ORD record
ord-7e0186dbfd86435394173dc2ef718fb8
Source dataset
uspto-grants-2002_05
Patent number
US06391915B2

Reaction notes

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