HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 22462504, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Oxonium, trimethyl-, tetrafluoroborate(1-) (1:1) | HCID 2735153 | — |
| Reactant | HCID 18516368 | HCID 18516368 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 22462504 | HCID 22462504 | — |
Reaction Steps
A solution of 8-chloro-1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinolin-4-one (200 mg, 0.9 mmol) in dichloromethane (20 ml) is stirred with trimethyloxonium tetrafluoroborate (134 mg, 0.9 mmol) for 24 hours at room temperature. After triethylamine (0.13 ml, 0.9 mmol) is added, the batch is concentrated by evaporation and purified by column chromatography (SiO2, 40% moist) with ethyl acetate-hexane: 180 mg (85%) of product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06391887B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-d7bd35535dcd48ee8d00785ede8db954 |
| Source note | uspto-grants-2002_05 |