Lawesson's reagent → HCID 22462471, compound

HRID 1936998Notes

Reaction equation

HRID 1936998 reaction equation
[Cl:1][C:2]1[C:11]2[NH:10][C:9](=O)[CH:8]3[CH2:13][CH2:14][CH2:15][CH:7]3[C:6]=2[CH:5]=[C:4]([Cl:16])[CH:3]=1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:26])=CC=1>C1COCC1>[Cl:1][C:2]1[C:11]2[NH:10][C:9](=[S:26])[CH:8]3[CH2:13][CH2:14][CH2:15][CH:7]3[C:6]=2[CH:5]=[C:4]([Cl:16])[CH:3]=1

Participants

4

Reactant 2

HCID 87949Lawesson's reagentHCID 22462444HCID 22462444, compound

Product 1

HCID 22462471HCID 22462471, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

6,8-Dichloro-1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinolin-4-one (100 mg, 0.39 mmol) is heated with Lawesson's reagent (412 mg, 1.02 mmol) for 2 hours in THF (20 ml). The batch is concentrated by evaporation and purified by column chromatography (SiO2) with ethyl acetate-hexane: 100 mg (94%) of product.

Workup

  1. concentrationThe batch is concentrated by evaporation
  2. custompurified by column chromatography (SiO2) with ethyl acetate-hexane

Sources & evidence

ORD record
ord-1285455414f74d4a8bcea32aeb678a60
Source dataset
uspto-grants-2002_05
Patent number
US06391887B1

Reaction notes

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