反应详情

A solution of 1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinolin-4-one (374 mg, 2.0 mmol) in DMF (10 ml) is mixed with N-bromosuccinimide (356 mg, 2.0 mmol). After 15 minutes of stirring at room temperature, the batch is heated for 15 minutes to 100° C., diluted with water and extracted with methyl-tert-butyl ether. The combined extracts are dried (Na2SO4) and concentrated by evaporation in a vacuum. The residue is purified on silica gel with ethyl acetate-hexane: 470 mg (88%) of product.

1. temperaturethe batch is heated for 15 minutes to 100° C.
2. extractionextracted with methyl-tert-butyl ether
3. dry with materialThe combined extracts are dried (Na2SO4)
4. concentrationconcentrated by evaporation in a vacuum
5. customThe residue is purified on silica gel with ethyl acetate-hexane