Magnesium → HCID 22462484, compound

HRID 1937001Notes

Reaction equation

HRID 1937001 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:12]=[CH:11][C:10]2[NH:9][C:8](=[O:13])[C:7]3[CH2:14][CH2:15][CH2:16][C:6]=3[C:5]=2[CH:4]=1.[Mg]>>[F:18][C:2]([F:1])([F:17])[C:3]1[CH:12]=[CH:11][C:10]2[NH:9][C:8](=[O:13])[CH:7]3[CH2:14][CH2:15][CH2:16][CH:6]3[C:5]=2[CH:4]=1

Participants

3

Reactant 2

HCID 5462224MagnesiumHCID 22462465HCID 22462465, compound

Product 1

HCID 22462484HCID 22462484, compoundYield 50.1%

Procedure

Analogously to Example 7, 8-(trifluoromethyl)-1,2,3,5-tetrahydrocyclopenta[c]quinolin-4-one (1.08 g, 4.3 mmol) is reacted with magnesium (2.24 g, 92 mmol) to form 0.55 g (50%) of product.

Sources & evidence

ORD record
ord-9ef563855d1c482f99277ed6f920d619
Source dataset
uspto-grants-2002_05
Patent number
US06391887B1

Reaction notes

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