HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 22462459, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | HCID 22052537 | HCID 22052537 | — |
| Reactant | HCID 178418546 | HCID 178418546 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 22462459 | HCID 22462459 | 38.3% |
Reaction Steps
A solution of 8-bromo-1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinolin-4-one (230 mg, 0.86 mmol) in DMF (20 ml) is mixed with copper(I) cyanide (77 mg, 0.86 mmol) and refluxed for 16 hours. The batch is diluted dichloromethane, washed with saturated NH4Cl, dried (Na2SO4) and concentrated by evaporation in a vacuum. Purification on silica gel with ethyl acetate-hexane yields 70 mg (38%) of product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06391887B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-d3311b65f24e4ec78984cfebd21e97e7 |
| Source note | uspto-grants-2002_05 |