反应详情

A solution of 8-bromo-1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinolin-4-one (230 mg, 0.86 mmol) in DMF (20 ml) is mixed with copper(I) cyanide (77 mg, 0.86 mmol) and refluxed for 16 hours. The batch is diluted dichloromethane, washed with saturated NH4Cl, dried (Na2SO4) and concentrated by evaporation in a vacuum. Purification on silica gel with ethyl acetate-hexane yields 70 mg (38%) of product.

1. temperaturerefluxed for 16 hours
2. washwashed with saturated NH4Cl
3. dry with materialdried (Na2SO4)
4. concentrationconcentrated by evaporation in a vacuum
5. customPurification on silica gel with ethyl acetate-hexane