反应详情

8-Cyano-1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinolin-4-one (70 mg, 0.33 mmol) is heated to 80° C. with Lawesson's reagent (146 mg, 0.36 mmol) for 2 hours in DME (20 ml). The batch is concentrated by evaporation and purified by column chromatography (SiO2) with ethyl acetate-hexane: 50 mg (66%) of product.

1. concentrationThe batch is concentrated by evaporation
2. custompurified by column chromatography (SiO2) with ethyl acetate-hexane