HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lawesson's reagent → 8-Cyano-1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinoline-4-thione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lawesson's reagent | HCID 87949 | — |
| Reactant | HCID 22462459 | HCID 22462459 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | 8-Cyano-1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinoline-4-thione | HCID 22462455 | — |
Reaction Steps
8-Cyano-1,2,3,3a,5,9b-hexahydrocyclopenta[c]quinolin-4-one (70 mg, 0.33 mmol) is heated to 80° C. with Lawesson's reagent (146 mg, 0.36 mmol) for 2 hours in DME (20 ml). The batch is concentrated by evaporation and purified by column chromatography (SiO2) with ethyl acetate-hexane: 50 mg (66%) of product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06391887B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-1b5d455f0c6a4eee847d9d5c64da65a6 |
| Source note | uspto-grants-2002_05 |