Acetic Anhydride → HCID 70023899, compound

HRID 1937042Notes

Reaction equation

HRID 1937042 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]2[CH2:15][CH:14]3[N:16]([CH3:17])[CH:10]([CH2:11][CH2:12][CH2:13]3)[CH:9]=2)[CH:5]=[CH:6][CH:7]=1.[C:18]([O:21][C:22](=[O:24])[CH3:23])(=[O:20])[CH3:19]>ClCCl>[C:18]([OH:21])(=[O:20])[CH3:19].[C:22]([NH:1][C:2]1[CH:3]=[C:4]([C:8]2[CH2:9][CH:10]3[N:16]([CH3:17])[CH:14]([CH2:13][CH2:12][CH2:11]3)[CH:15]=2)[CH:5]=[CH:6][CH:7]=1)(=[O:24])[CH3:23]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 22463286HCID 22463286, compound

Product 1

HCID 70023899HCID 70023899, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of (±)-3-(3-aminophenyl)-9-methyl-9-azabicyclo[3.3.1]non-2-ene (0.43 g, 1.9 mmol) in dichloromethane was added dropwise, Acetic Acid anhydride (0.25 g, 0.23 ml) at 0° C. The mixture was triturated with petroleum ether (2×10 ml), followed by diethyl ether (10 ml). Yield 0.34 g, 55%. Mp. 59.9-63.4° C.

Workup

  1. customat 0° C
  2. customThe mixture was triturated with petroleum ether (2×10 ml)

Sources & evidence

ORD record
ord-80319603602445e5ae163a37f79226ab
Source dataset
uspto-grants-2002_05
Patent number
US06392045B1

Reaction notes

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