Ammonium Hydroxide → HCID 22462783, compound

HRID 1937183Notes

Reaction equation

HRID 1937183 reaction equation
[N:1]1([CH2:6][CH2:7][O:8][C:9]2[CH:14]=[CH:13][C:12]([C:15]([C:17]3[C:18]4[CH:42]=[CH:41][C:40]([O:43]CC5C=CC=CC=5)=[CH:39][C:19]=4[S:20][C:21]=3[C:22]3[CH:27]=[CH:26][C:25]([O:28][Si](C(C)C)(C(C)C)C(C)C)=[CH:24][CH:23]=3)=O)=[CH:11][CH:10]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH4+:51].[OH-]>C(Cl)(Cl)Cl>[OH:43][C:40]1[CH:41]=[CH:42][C:18]2[C:17]([CH2:15][C:12]3[CH:11]=[CH:10][C:9]([O:8][CH2:7][CH2:6][N:1]4[CH2:2][CH2:3][CH2:4][CH2:5]4)=[CH:14][CH:13]=3)=[C:21]([C:22]3[CH:27]=[CH:26][C:25]([O:28][CH2:2][CH2:3][CH2:4][C:5]#[N:51])=[CH:24][CH:23]=3)[S:20][C:19]=2[CH:39]=1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 22462734HCID 22462734, compound

Product 1

HCID 22462783HCID 22462783, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

By essentially following the proceedure described in Example 14, Part D, the title compound was prepared as a foam starting from 6-benzyloxy-2-(4-triisopropylsilyloxyphenyl)benzo[b]thiophene-3-yl 4-[2-(1-pyrrolidinyl)ethoxy]phenyl ketone (Part B) in quantitative yield following MPLC (SiO2; 0.5% in CHCl3 sat'd with NH4OH).

Sources & evidence

ORD record
ord-db39ea53c2e84bd1be100ed8a36eb611
Source dataset
uspto-grants-2002_05
Patent number
US06391901B1

Reaction notes

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