反应详情

A suspension of 2-(4-hydroxyphenyl)-3-[4-[2-(1-pyrrolidinyl)ethoxy]benzyl]benzo[b]thiophene (102 mg) and cesium carbonate (386 mg) in DMF (3.0 mL) was treated with bromoacetonitrile (20 μL) while stirring at ambient temperature. Stirring was continued for 2 h and the reaction mixture was diluted with brine (30 mL) and extracted with EtOAc (20 mL×3). The combined organic layers were dried with sodium sulfate and concentrated under reduced pressure. Chromatography with Et3N-EtOAc (0-5%) afforded the product (98 mg).

1. stirringStirring
2. extractionextracted with EtOAc (20 mL×3)
3. dry with materialThe combined organic layers were dried with sodium sulfate
4. concentrationconcentrated under reduced pressure