HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isonicotinic Acid → 3-[4-[2-(1-Pyrrolidinyl)ethoxy]benzyl]-2-[4-[2-(4-pyridinylcarbonylamino)ethyl]phenyl]benzo[b]thiophene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isonicotinic Acid | HCID 5922 | — |
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 2-[4-(2-Aminoethyl)phenyl]-3-[4-[2-(1-pyrrolidinyl)ethoxy]benzyl]benzo[b]thiophene | HCID 22462716 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-[4-[2-(1-Pyrrolidinyl)ethoxy]benzyl]-2-[4-[2-(4-pyridinylcarbonylamino)ethyl]phenyl]benzo[b]thiophene | HCID 22462777 | 33% |
Reaction Steps
A solution of 2-[4-(2-aminoethyl)phenyl]-3-[4-[2-(1-pyrrolidinyl)ethoxy]benzyl]benzo[b]thiophene (111 mg) in dichloromethane (3.0 mL) was treated isonicotinic acid (35 mg) and DCC (50 mg) sequentially and allowed to stir at ambient temperature for 25 h. The reaction mixture was then concentrated and fractionated by column chromatography with Et3N:MeOH:EtOAc (5:10:85) to afford the product (45 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06391901B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-f54d6456eed04f3481cf8e620ec84e12 |
| Source note | uspto-grants-2002_05 |