反应详情

A solution of 2-[4-(2-aminoethyl)phenyl]-3-[4-[2-(1-pyrrolidinyl)ethoxy]benzyl]benzo[b]thiophene (111 mg) in dichloromethane (3.0 mL) was treated isonicotinic acid (35 mg) and DCC (50 mg) sequentially and allowed to stir at ambient temperature for 25 h. The reaction mixture was then concentrated and fractionated by column chromatography with Et3N:MeOH:EtOAc (5:10:85) to afford the product (45 mg).

1. concentrationThe reaction mixture was then concentrated