HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 17942084, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 17942082 | HCID 17942082 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 17942084 | HCID 17942084 | 93.1% |
Reaction Steps
To a solution of 1-(6-chloronaphth-2-ylsulphonyl)-4-[4-(2-tert-butyloxycarbonylaminomethyl-pyridyl)benzoyl]piperazine (90 mg, 1.45 mmol) in tetrahydrofuran (2 ml) was added ˜4M methanolic HCl (2 ml) and the resultant mixture stirred for four hours at ambient temperature. Removal of the solvent, after filtration, gave 1-(6-chloronaphth-2-ylsulphonyl)-4-[4-(2-aminomethyl-pyridyl)benzoyl]piperazine (75 mg, 1.35 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06395731B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-7aa440e1f9fb4a30915f6dce3dea132f |
| Source note | uspto-grants-2002_05 |