Hydrochloric Acid → HCID 17942084, compound

HRID 1937323Notes

Reaction equation

HRID 1937323 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([S:12]([N:15]1[CH2:20][CH2:19][N:18]([C:21](=[O:43])[C:22]3[CH:27]=[CH:26][C:25]([C:28]4[C:29]([CH2:34][NH:35]C(OC(C)(C)C)=O)=[N:30][CH:31]=[CH:32][CH:33]=4)=[CH:24][CH:23]=3)[CH2:17][CH2:16]1)(=[O:14])=[O:13])[CH:6]=[CH:5]2.Cl>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([S:12]([N:15]1[CH2:20][CH2:19][N:18]([C:21](=[O:43])[C:22]3[CH:23]=[CH:24][C:25]([C:28]4[C:29]([CH2:34][NH2:35])=[N:30][CH:31]=[CH:32][CH:33]=4)=[CH:26][CH:27]=3)[CH2:17][CH2:16]1)(=[O:14])=[O:13])[CH:6]=[CH:5]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 17942082HCID 17942082, compound

Product 1

HCID 17942084HCID 17942084, compoundYield 93.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 1-(6-chloronaphth-2-ylsulphonyl)-4-[4-(2-tert-butyloxycarbonylaminomethyl-pyridyl)benzoyl]piperazine (90 mg, 1.45 mmol) in tetrahydrofuran (2 ml) was added ˜4M methanolic HCl (2 ml) and the resultant mixture stirred for four hours at ambient temperature. Removal of the solvent, after filtration, gave 1-(6-chloronaphth-2-ylsulphonyl)-4-[4-(2-aminomethyl-pyridyl)benzoyl]piperazine (75 mg, 1.35 mmol).

Workup

  1. customRemoval of the solvent
  2. filtrationafter filtration

Sources & evidence

ORD record
ord-7aa440e1f9fb4a30915f6dce3dea132f
Source dataset
uspto-grants-2002_05
Patent number
US06395731B1

Reaction notes

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