HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Methoxide → (+)-trans-1-(3,4-Dichlorobenzamido)-2-hydroxy-7-(pyrrolidinoformamido)tetraline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | (+)-trans-1-(3,4-Dichlorobenzamido)-2-acetoxy-7-(pyrrolidinoformamido)tetraline | HCID 21338527 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (+)-trans-1-(3,4-Dichlorobenzamido)-2-hydroxy-7-(pyrrolidinoformamido)tetraline | HCID 21338529 | — |
Reaction Steps
A solution of 116 (0.27 g) in MeOH (10 mL) was treated with 0.135 M sodium methoxide (4.9 mL) in MeOH. After 4 h, the solvent was evaporated, the residue was suspended in H2O, and the solid was collected by filtration. The solid was crystallized from EtOAc-ether to give a tan powder, m.p. 206-208° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06395735B2 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-00a7c8bd925e41b2bbb193d901cc3190 |
| Source note | uspto-grants-2002_05 |