反应详情

4-Chloropyrido [2,3-d]pyrimidine (0.15 g, 0.91 mmol) was carefully added to a solution of aniline (0.15 g, 1.61 mmol) on water (1.5 mL). The solution was heated for 0.5 hour on a steam bath, cooled, and then basified with conc. ammonium hydroxide. The crude precipitate was collected by filtration and recrystallized from 95% ethanol to give the title product as yellow crystals (0.054 g, 27%). MP 258° C.; LC-MS: 223 (MH+).

1. temperatureThe solution was heated for 0.5 hour on a steam bath
2. temperaturecooled
3. filtrationThe crude precipitate was collected by filtration
4. customrecrystallized from 95% ethanol