Benzenamine, 3-ethynyl- → HCID 18473299, compound

HRID 1937396Notes

Reaction equation

HRID 1937396 reaction equation
Cl[C:2]1[C:3]2[CH:10]=[CH:9][N:8]([CH2:11][CH2:12][O:13][CH2:14][CH2:15][O:16][CH3:17])[C:4]=2[N:5]=[CH:6][N:7]=1.[NH2:18][C:19]1[CH:20]=[C:21]([C:25]#[CH:26])[CH:22]=[CH:23][CH:24]=1>CO>[C:25]([C:21]1[CH:20]=[C:19]([NH:18][C:2]2[C:3]3[CH:10]=[CH:9][N:8]([CH2:11][CH2:12][O:13][CH2:14][CH2:15][O:16][CH3:17])[C:4]=3[N:5]=[CH:6][N:7]=2)[CH:24]=[CH:23][CH:22]=1)#[CH:26]

Participants

4

Reactant 2

HCID 104682Benzenamine, 3-ethynyl-HCID 110863424-Chloro-7-[2-(2-methoxyethoxy)ethyl]-7H-pyrrolo[2,3-d]pyrimidine

Product 1

HCID 18473299HCID 18473299, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Utilizing a procedure analogous to that described in Example 47, this product was prepared in 81% yield from 4-chloro-7-[2-(2-methoxy-ethoxy)-ethyl]-7H-pyrrolo[2,3-d]pyrimidine (1.0 eq) and m-aminophenyl acetylene (1.2 eq) in methanol. M.P. 240-241° C.; LC-MS: 336 (M+); RP18HPLC RT: 4.29 min.

Sources & evidence

ORD record
ord-09ae564fb954459bad13ce4e746ae82b
Source dataset
uspto-grants-2002_05
Patent number
US06395733B1

Reaction notes

Loading…