HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenamine, 3-ethynyl- → HCID 18473299, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenamine, 3-ethynyl- | HCID 104682 | — |
| Reactant | 4-Chloro-7-[2-(2-methoxyethoxy)ethyl]-7H-pyrrolo[2,3-d]pyrimidine | HCID 11086342 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 18473299 | HCID 18473299 | 81% |
Reaction Steps
Utilizing a procedure analogous to that described in Example 47, this product was prepared in 81% yield from 4-chloro-7-[2-(2-methoxy-ethoxy)-ethyl]-7H-pyrrolo[2,3-d]pyrimidine (1.0 eq) and m-aminophenyl acetylene (1.2 eq) in methanol. M.P. 240-241° C.; LC-MS: 336 (M+); RP18HPLC RT: 4.29 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06395733B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-09ae564fb954459bad13ce4e746ae82b |
| Source note | uspto-grants-2002_05 |