Hydrochloric Acid → HCID 22734135, compound

Participants

Reaction Steps

Ethyl 4-[(3,5-dichloro-4-pyridyl)carbamoyl]-7-methoxybenzofuran-2-carboxylate (6.1 g) was dissolved in methanol (80 ml), 1 N aqueous NaOH (40 ml) was added thereto under cooling on ice, and the mixture was returned to room temperature and stirred for 2 hours. The reaction mixture was acidified by dropwise adding 1 N aqueous HCl under cooling on ice, and the precipitated crystals were collected by filtration and washed with water to give Compound K (5.6 g, 98%).

Provenance & Evidence